MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis

Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. We develop a set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC. Many predictions are directly validated by dCas9-based epigenetic ed...

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Bibliografski detalji
Izdano u:Genome Biol
Glavni autori: Tong, Yin, Sun, Jianlong, Wong, Chi Fat, Kang, Qingzheng, Ru, Beibei, Wong, Ching Ngar, Chan, April Sheila, Leung, Suet Yi, Zhang, Jiangwen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989391/
https://ncbi.nlm.nih.gov/pubmed/29871649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1442-0
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