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MICMIC: identification of DNA methylation of distal regulatory regions with causal effects on tumorigenesis
Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. We develop a set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC. Many predictions are directly validated by dCas9-based epigenetic ed...
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| Izdano u: | Genome Biol |
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| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5989391/ https://ncbi.nlm.nih.gov/pubmed/29871649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1442-0 |
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