Multi-omics “upstream analysis” of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer

We present an “upstream analysis” strategy for causal analysis of multiple “-omics” data. It analyzes promoters using the TRANSFAC database, combines it with an analysis of the upstream signal transduction pathways and identifies master regulators as potential drug targets for a pathological process...

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Dades bibliogràfiques
Publicat a:EuPA Open Proteom
Autors principals: Kel, Alexander E., Stegmaier, Philip, Valeev, Tagir, Koschmann, Jeannette, Poroikov, Vladimir, Kel-Margoulis, Olga V., Wingender, Edgar
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
Matèries:
Special Section: Contributions from PATHPROT, the Annual International Forum for Pathway Analysis in Proteomics (Oeiras, Portugal)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988513/
https://ncbi.nlm.nih.gov/pubmed/29900117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.euprot.2016.09.002
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