Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs

Herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit antigen is included in many preclinical candidate vaccines. The rationale for including gD2 is to produce antibodies that block crucial gD2 epitopes involved in virus entry and cell-to-cell spread. HSV-2 gD2 was the only antigen in the...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Hook, Lauren M., Cairns, Tina M., Awasthi, Sita, Brooks, Benjamin D., Ditto, Noah T., Eisenberg, Roselyn J., Cohen, Gary H., Friedman, Harvey M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988323/
https://ncbi.nlm.nih.gov/pubmed/29791513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007095
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