CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells

Cancer stem cells promote neoplastic growth, in part by deregulating asymmetric cell division and enhancing self-renewal. To uncover mechanisms and potential therapeutic targets in glioma stem cell (GSC) self-renewal, we performed a genetic suppressor screen for kinases to reverse the tumor phenotyp...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Mukherjee, Subhas, Tucker-Burden, Carol, Kaissi, Emily, Newsam, Austin, Duggireddy, Hithardhi, Chau, Monica, Zhang, Changming, Diwedi, Bhakti, Rupji, Manali, Seby, Sandra, Kowalski, Jeanne, Kong, Jun, Read, Renee, Brat, Daniel J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987254/
https://ncbi.nlm.nih.gov/pubmed/29742423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.016
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