Geranylgeraniol Prevents Statin-Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy

The present study investigated the cytotoxic effects of statins (atorvastatin (ATR) and simvastatin (SIM), resp.) and methyl-beta-cyclodextrin (MβCD), at their respective IC(50) concentrations, on muscle regeneration in the in vitro model of murine C2C12 myoblasts. Cotreatment with mevalonate (MEV),...

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Bibliografiske detaljer
Udgivet i:Oxid Med Cell Longev
Main Authors: Jaśkiewicz, Anna, Pająk, Beata, Litwiniuk, Anna, Urbańska, Kaja, Orzechowski, Arkadiusz
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987243/
https://ncbi.nlm.nih.gov/pubmed/29951166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/6463807
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