Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3

Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), whic...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Clark, Heather L., Abbondante, Serena, Minns, Martin S., Greenberg, Elyse N., Sun, Yan, Pearlman, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986955/
https://ncbi.nlm.nih.gov/pubmed/29896200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01182
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