An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation

Genome-wide association studies (GWASs) have reproducibly associated variants within intergenic regions of 1p36.12 locus with osteoporosis, but the functional roles underlying these noncoding variants are unknown. Through an integrative functional genomic and epigenomic analyses, we prioritized rs64...

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Udgivet i:Am J Hum Genet
Main Authors: Chen, Xiao-Feng, Zhu, Dong-Li, Yang, Man, Hu, Wei-Xin, Duan, Yuan-Yuan, Lu, Bing-Jie, Rong, Yu, Dong, Shan-Shan, Hao, Ruo-Han, Chen, Jia-Bin, Chen, Yi-Xiao, Yao, Shi, Thynn, Hlaing Nwe, Guo, Yan, Yang, Tie-Lin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986728/
https://ncbi.nlm.nih.gov/pubmed/29706346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2018.03.001
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