Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles

BACKGROUND: Exacerbations of asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous. OBJECTIVE: We sought to investigate the sputum cellular, mediator, and microbiome profiles of both asthma and COPD exacerbations. METHODS: Patients with severe asthma or moderate-to-severe COPD we...

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Udgivet i:J Allergy Clin Immunol
Main Authors: Ghebre, Michael A., Pang, Pee Hwee, Diver, Sarah, Desai, Dhananjay, Bafadhel, Mona, Haldar, Koirobi, Kebadze, Tatiana, Cohen, Suzanne, Newbold, Paul, Rapley, Laura, Woods, Joanne, Rugman, Paul, Pavord, Ian D., Johnston, Sebastian L., Barer, Michael, May, Richard D., Brightling, Christopher E.
Format: Artigo
Sprog:Inglês
Udgivet: The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. 2018
Fag:
Asthma and Lower Airway Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986707/
https://ncbi.nlm.nih.gov/pubmed/29709671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.04.013
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