Diminished gallbladder filling, increased fecal bile acids, and promotion of colon epithelial cell proliferation and neoplasia in fibroblast growth factor 15-deficient mice

Fibroblast growth factor-19 (human FGF19; murine FGF15) suppresses bile acid synthesis. In FGF19 deficiency, diarrhea resulting from bile acid spillage into the colon mimics irritable bowel syndrome. To seek other consequences of FGF19/15 deficiency, we used Fgf15(-/-) and wild-type (WT) mice to ass...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cheng, Kunrong, Metry, Melissa, Felton, Jessica, Shang, Aaron C., Drachenberg, Cinthia B., Xu, Su, Zhan, Min, Schumacher, Justin, Guo, Grace L., Polli, James E., Raufman, Jean-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986650/
https://ncbi.nlm.nih.gov/pubmed/29876009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25385
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