Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins

Destruxins, secondary metabolites of entomopathogenic fungi, exert a wide variety of interesting characteristics ranging from antiviral to anticancer effects. Although their mode of action was evaluated previously, the molecular mechanisms of resistance development are unknown. Hence, we have establ...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Heilos, Daniela, Röhrl, Clemens, Pirker, Christine, Englinger, Bernhard, Baier, Dina, Mohr, Thomas, Schwaiger, Michaela, Iqbal, Shahid Muhammad, van Schoonhoven, Sushilla, Klavins, Kristaps, Eberhart, Tanja, Windberger, Ursula, Taibon, Judith, Sturm, Sonja, Stuppner, Hermann, Koellensperger, Gunda, Dornetshuber-Fleiss, Rita, Jäger, Walter, Lemmens-Gruber, Rosa, Berger, Walter
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2018
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986646/
https://ncbi.nlm.nih.gov/pubmed/29876015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25432
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