Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins

Destruxins, secondary metabolites of entomopathogenic fungi, exert a wide variety of interesting characteristics ranging from antiviral to anticancer effects. Although their mode of action was evaluated previously, the molecular mechanisms of resistance development are unknown. Hence, we have establ...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Heilos, Daniela, Röhrl, Clemens, Pirker, Christine, Englinger, Bernhard, Baier, Dina, Mohr, Thomas, Schwaiger, Michaela, Iqbal, Shahid Muhammad, van Schoonhoven, Sushilla, Klavins, Kristaps, Eberhart, Tanja, Windberger, Ursula, Taibon, Judith, Sturm, Sonja, Stuppner, Hermann, Koellensperger, Gunda, Dornetshuber-Fleiss, Rita, Jäger, Walter, Lemmens-Gruber, Rosa, Berger, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986646/
https://ncbi.nlm.nih.gov/pubmed/29876015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25432
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