Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins

Destruxins, secondary metabolites of entomopathogenic fungi, exert a wide variety of interesting characteristics ranging from antiviral to anticancer effects. Although their mode of action was evaluated previously, the molecular mechanisms of resistance development are unknown. Hence, we have establ...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Heilos, Daniela, Röhrl, Clemens, Pirker, Christine, Englinger, Bernhard, Baier, Dina, Mohr, Thomas, Schwaiger, Michaela, Iqbal, Shahid Muhammad, van Schoonhoven, Sushilla, Klavins, Kristaps, Eberhart, Tanja, Windberger, Ursula, Taibon, Judith, Sturm, Sonja, Stuppner, Hermann, Koellensperger, Gunda, Dornetshuber-Fleiss, Rita, Jäger, Walter, Lemmens-Gruber, Rosa, Berger, Walter
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986646/
https://ncbi.nlm.nih.gov/pubmed/29876015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25432
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