Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins

Destruxins, secondary metabolites of entomopathogenic fungi, exert a wide variety of interesting characteristics ranging from antiviral to anticancer effects. Although their mode of action was evaluated previously, the molecular mechanisms of resistance development are unknown. Hence, we have establ...

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Vydáno v:Oncotarget
Hlavní autoři: Heilos, Daniela, Röhrl, Clemens, Pirker, Christine, Englinger, Bernhard, Baier, Dina, Mohr, Thomas, Schwaiger, Michaela, Iqbal, Shahid Muhammad, van Schoonhoven, Sushilla, Klavins, Kristaps, Eberhart, Tanja, Windberger, Ursula, Taibon, Judith, Sturm, Sonja, Stuppner, Hermann, Koellensperger, Gunda, Dornetshuber-Fleiss, Rita, Jäger, Walter, Lemmens-Gruber, Rosa, Berger, Walter
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986646/
https://ncbi.nlm.nih.gov/pubmed/29876015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25432
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