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A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells
Many tumor cells produce vast amounts of lactate and acid, which have to be removed from the cell to prevent intracellular lactacidosis and suffocation of metabolism. In the present study, we show that proton-driven lactate flux is enhanced by the intracellular carbonic anhydrase CAII, which is colo...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5986270/ https://ncbi.nlm.nih.gov/pubmed/29809145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35176 |
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