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A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells

Many tumor cells produce vast amounts of lactate and acid, which have to be removed from the cell to prevent intracellular lactacidosis and suffocation of metabolism. In the present study, we show that proton-driven lactate flux is enhanced by the intracellular carbonic anhydrase CAII, which is colo...

詳細記述

保存先:
書誌詳細
出版年:eLife
主要な著者: Noor, Sina Ibne, Jamali, Somayeh, Ames, Samantha, Langer, Silke, Deitmer, Joachim W, Becker, Holger M
フォーマット: Artigo
言語:Inglês
出版事項: eLife Sciences Publications, Ltd 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986270/
https://ncbi.nlm.nih.gov/pubmed/29809145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35176
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