Phosphorylation of Tau protein correlates with changes in hippocampal theta oscillations and reduces hippocampal excitability in Alzheimer's model

Tau hyperphosphorylation at several sites, including those close to the microtubule domain region (MDr), is considered a key pathological event in the development of Alzheimer's disease (AD). Recent studies indicate that at the very early stage of this disease, increased phosphorylation in Tau&...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mondragón-Rodríguez, Siddhartha, Salas-Gallardo, Anahí, González-Pereyra, Perla, Macías, Martín, Ordaz, Benito, Peña-Ortega, Fernando, Aguilar-Vázquez, Azucena, Orta-Salazar, Erika, Díaz-Cintra, Sofía, Perry, George, Williams, Sylvain
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986208/
https://ncbi.nlm.nih.gov/pubmed/29632073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001187
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