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Tryptophanyl-tRNA synthetase mediates high-affinity tryptophan uptake into human cells

The tryptophan (Trp) transport system has a high affinity and selectivity toward Trp, and has been reported to exist in both human and mouse macrophages. Although this system is highly expressed in interferon-γ (IFN-γ)–treated cells and indoleamine 2,3-dioxygenase 1 (IDO1)–expressing cells, its iden...

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Pubblicato in:J Biol Chem
Autori principali: Miyanokoshi, Miki, Yokosawa, Takumi, Wakasugi, Keisuke
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986205/
https://ncbi.nlm.nih.gov/pubmed/29666190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001247
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