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Cyclic compressive loading activates angiotensin II type 1 receptor in articular chondrocytes and stimulates hypertrophic differentiation through a G‐protein‐dependent pathway

Angiotensin II type 1 receptor (AT1R) appears to have a mechanosensing function in a number of cell types. The purpose of this study was to examine whether AT1R expressed in articular chondrocytes is involved in osteoarthritis (OA) progression in vivo and whether cyclic compressive loading activates...

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Detalhes bibliográficos
Publicado no:FEBS Open Bio
Main Authors: Nakamura, Fumihisa, Tsukamoto, Ichiro, Inoue, Shinji, Hashimoto, Kazuhiko, Akagi, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986009/
https://ncbi.nlm.nih.gov/pubmed/29928576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12438
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