Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism

Neuroticism is a relatively stable personality trait characterised by negative emotionality (e.g., worry, guilt) 1; twin study heritability ranges 30 to 50% 2, and SNP-based heritability ranges 6 to 15% 3–6. Increased neuroticism is associated with poorer mental and physical health 7,8, translating...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Luciano, Michelle, Hagenaars, Saskia P, Davies, Gail, Hill, W David, Clarke, Toni-Kim, Shirali, Masoud, Harris, Sarah E, Marioni, Riccardo E, Liewald, David C, Fawns-Ritchie, Chloe, Adams, Mark J, Howard, David M, Lewis, Cathryn M, Gale, Catharine R., McIntosh, Andrew M, Deary, Ian J
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985926/
https://ncbi.nlm.nih.gov/pubmed/29255261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-017-0013-8
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