A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses

Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT2. STAT1 homodimers, known as γ-activated factor (GAF), activate transcription in response to all t...

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Bibliografiska uppgifter
I publikationen:Front Immunol
Huvudupphovsmän: Michalska, Agata, Blaszczyk, Katarzyna, Wesoly, Joanna, Bluyssen, Hans A. R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2018
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985295/
https://ncbi.nlm.nih.gov/pubmed/29892288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01135
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