Evidence against a role for NLRP3-driven islet inflammation in db/db mice

OBJECTIVES: Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 inflammasome and secretion of its target interleukin-1β (IL-1β) have been implicated in pancreatic β cell failure in T2D. Specific targeting of the NLRP3 inflammasome to prevent pancreatic β...

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Bibliografiske detaljer
Udgivet i:Mol Metab
Main Authors: Kammoun, H.L., Allen, T.L., Henstridge, D.C., Barre, S., Coll, R.C., Lancaster, G.I., Cron, L., Reibe, S., Chan, J.Y., Bensellam, M., Laybutt, D.R., Butler, M.S., Robertson, A.A.B., O'Neill, L.A., Cooper, M.A., Febbraio, M.A.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985230/
https://ncbi.nlm.nih.gov/pubmed/29478918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.02.001
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