Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis

Genetic studies have elucidated critical roles of Piwi proteins in germline development in animals, but whether Piwi is an actual disease gene in human infertility remains unknown. We report germline mutations in human Piwi (Hiwi) in patients with azoospermia that prevent its ubiquitination and degr...

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Dades bibliogràfiques
Publicat a:Cell
Autors principals: Gou, Lan-Tao, Kang, Jun-Yan, Dai, Peng, Wang, Xin, Li, Feng, Zhao, Shuang, Zhang, Man, Hua, Min-Min, Lu, Yi, Zhu, Yong, Li, Zheng, Chen, Hong, Wu, Li-Gang, Li, Dangsheng, Fu, Xiang-Dong, Li, Jinsong, Shi, Hui-Juan, Liu, Mo-Fang
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985145/
https://ncbi.nlm.nih.gov/pubmed/28552346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.04.034
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