Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis

Genetic studies have elucidated critical roles of Piwi proteins in germline development in animals, but whether Piwi is an actual disease gene in human infertility remains unknown. We report germline mutations in human Piwi (Hiwi) in patients with azoospermia that prevent its ubiquitination and degr...

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Gepubliceerd in:Cell
Hoofdauteurs: Gou, Lan-Tao, Kang, Jun-Yan, Dai, Peng, Wang, Xin, Li, Feng, Zhao, Shuang, Zhang, Man, Hua, Min-Min, Lu, Yi, Zhu, Yong, Li, Zheng, Chen, Hong, Wu, Li-Gang, Li, Dangsheng, Fu, Xiang-Dong, Li, Jinsong, Shi, Hui-Juan, Liu, Mo-Fang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985145/
https://ncbi.nlm.nih.gov/pubmed/28552346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.04.034
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