Using CRISPR/Cas9 to Knock out Amylase in Acinar Cells Decreases Pancreatitis-Induced Autophagy

Pancreatic cancer is a malignant neoplasm that originates from acinar cells. Acinar cells get reprogrammed to become duct cells, resulting in pancreatic cancer. Pancreatitis is an acinar cell inflammation, leading to “impaired autophagy flux”. Pancreatitis promotes acinar-to-ductal transdifferentiat...

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Библиографические подробности
Опубликовано в: :Biomed Res Int
Главные авторы: Yasunaga, Kohei, Ito, Tetsuhide, Miki, Masami, Ueda, Keijiro, Fujiyama, Takashi, Tachibana, Yuichi, Fujimori, Nao, Kawabe, Ken, Ogawa, Yoshihiro
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985122/
https://ncbi.nlm.nih.gov/pubmed/29888283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/8719397
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