Using CRISPR/Cas9 to Knock out Amylase in Acinar Cells Decreases Pancreatitis-Induced Autophagy

Pancreatic cancer is a malignant neoplasm that originates from acinar cells. Acinar cells get reprogrammed to become duct cells, resulting in pancreatic cancer. Pancreatitis is an acinar cell inflammation, leading to “impaired autophagy flux”. Pancreatitis promotes acinar-to-ductal transdifferentiat...

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Détails bibliographiques
Publié dans:Biomed Res Int
Auteurs principaux: Yasunaga, Kohei, Ito, Tetsuhide, Miki, Masami, Ueda, Keijiro, Fujiyama, Takashi, Tachibana, Yuichi, Fujimori, Nao, Kawabe, Ken, Ogawa, Yoshihiro
Format: Artigo
Langue:Inglês
Publié: Hindawi 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985122/
https://ncbi.nlm.nih.gov/pubmed/29888283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/8719397
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