Using CRISPR/Cas9 to Knock out Amylase in Acinar Cells Decreases Pancreatitis-Induced Autophagy

Pancreatic cancer is a malignant neoplasm that originates from acinar cells. Acinar cells get reprogrammed to become duct cells, resulting in pancreatic cancer. Pancreatitis is an acinar cell inflammation, leading to “impaired autophagy flux”. Pancreatitis promotes acinar-to-ductal transdifferentiat...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Yasunaga, Kohei, Ito, Tetsuhide, Miki, Masami, Ueda, Keijiro, Fujiyama, Takashi, Tachibana, Yuichi, Fujimori, Nao, Kawabe, Ken, Ogawa, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985122/
https://ncbi.nlm.nih.gov/pubmed/29888283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/8719397
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