A gut–brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus

OBJECTIVE: Bile acids have been implicated as important regulators of glucose metabolism via activation of FXR and GPBAR1. We have previously shown that FGF19 can modulate glucose handling by suppressing the activity of hypothalamic AGRP/NPY neurons. As bile acids stimulate the release of FGF19/FGF1...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Liu, Shunmei, Marcelin, Genevieve, Blouet, Clemence, Jeong, Jae Hoon, Jo, Young-Hwan, Schwartz, Gary J., Chua, Streamson
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985052/
https://ncbi.nlm.nih.gov/pubmed/29290621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.12.003
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