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Sarcoplasmic Reticulum Ca(2+) Release Uses a Cascading Network of Intra-SR and Channel Countercurrents

In muscle, Ca(2+) release from the sarcoplasmic reticulum (SR) into the cytosol is mediated through the ryanodine receptors (RyRs) and sustained by countercurrents that keep the SR membrane potential near 0 mV. Likewise, Ca(2+) reuptake by the sarco/endoplasmic reticulum Ca(2+) ATPase pump requires...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Zsolnay, Vilmos, Fill, Michael, Gillespie, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984985/
https://ncbi.nlm.nih.gov/pubmed/29401443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.11.3775
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