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Efficient gene silencing in brain tumors with hydrophobically modified siRNAs

Glioblastoma (GBM) is the most common and lethal form of primary brain tumor with dismal median and two-year survivals of 14.5 months and 18%, respectively. The paucity of new therapeutic agents stems from the complex biology of a highly adaptable tumor that uses multiple survival and proliferation...

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Publicat a:Mol Cancer Ther
Autors principals: Osborn, Maire F., Coles, Andrew H., Golebiowski, Diane, Echeverria, Dimas, Moazami, Michael P., Watts, Jonathan K., Sena-Esteves, Miguel, Khvorova, Anastasia
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984726/
https://ncbi.nlm.nih.gov/pubmed/29654062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-1144
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