Combination approach for detecting different types of alterations in circulating tumor DNA in leiomyosarcoma

PURPOSE: The clinical utility of circulating tumor DNA (ctDNA) monitoring has been shown in tumors that harbor highly recurrent mutations. Leiomyosarcoma (LMS) represents a type of tumor with a wide spectrum of heterogeneous genomic abnormalities; thus, targeting hotspot mutations or a narrow genomi...

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Pubblicato in:Clin Cancer Res
Autori principali: Przybyl, Joanna, Chabon, Jacob J., Spans, Lien, Ganjoo, Kristen N., Vennam, Sujay, Newman, Aaron M., Forgó, Erna, Varma, Sushama, Zhu, Shirley, Debiec-Rychter, Maria, Alizadeh, Ash A., Diehn, Maximilian, van de Rijn, Matt
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984700/
https://ncbi.nlm.nih.gov/pubmed/29463554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3704
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