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LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
Mutations in leucine-rich repeat kinase (LRRK2) are the most common cause of heritable Parkinson’s disease (PD), and the most common mutations in LRRK2 lead to elevated kinase activity. For these reasons, inhibitors targeting LRRK2 have been the subject of intense research and development. However,...
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| Publicado no: | Acta Neuropathol Commun |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5984465/ https://ncbi.nlm.nih.gov/pubmed/29855356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0550-0 |
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