Promoter of lncRNA gene PVT1 is a tumor suppressor DNA boundary element

Noncoding mutations in cancer genomes are frequent but challenging to interpret. PVT1 encodes an oncogenic lncRNA, but recurrent translocations and deletions in human cancers suggest alternative mechanisms. Here we show that PVT1 promoter has tumor suppressor function independent of PVT1 lncRNA. CRI...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Cho, Seung Woo, Xu, Jin, Sun, Ruping, Mumbach, Maxwell R., Carter, Ava C., Chen, Y. Grace, Yost, Kathryn E., Kim, Jeewon, He, Jing, Nevins, Stephanie, Chin, Suet-Feung, Caldas, Carlos, Liu, S. John, Horbeck, Max, Lim, Daniel A., Weissman, Jonathan S., Curtis, Christina, Chang, Howard Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984165/
https://ncbi.nlm.nih.gov/pubmed/29731168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.068
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