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High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1
Fibroblast growth factor receptor 1 (FGFR1) is a plasma membrane protein that transmits signals from the extracellular environment, regulating cell homeostasis and function. Dysregulation of FGFR1 leads to the development of human cancers and noncancerous diseases. Numerous tumors overproduce FGFR1,...
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| Veröffentlicht in: | Int J Mol Sci |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5983756/ https://ncbi.nlm.nih.gov/pubmed/29748524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19051435 |
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