sNASP inhibits TLR signaling to regulate immune response in sepsis

Many Toll-like receptors (TLRs) signal through TNF receptor–associated factor 6 (TRAF6) to activate innate immune responses. Here, we show that somatic nuclear autoantigenic sperm protein (sNASP) binds to TRAF6 to prevent TRAF6 autoubiquitination in unstimulated macrophages. Following LPS stimulatio...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Yang, Feng-Ming, Zuo, Yong, Zhou, Wei, Xia, Chuan, Hahm, Bumsuk, Sullivan, Mark, Cheng, Jinke, Chang, Hui-Ming, Yeh, Edward T.H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983344/
https://ncbi.nlm.nih.gov/pubmed/29733298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95720
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