Coordination of receptor tyrosine kinase signaling and interfacial tension dynamics drive radial intercalation and tube elongation

We sought to understand how cells collectively elongate epithelial tubes. We first used 3D culture and biosensor imaging to demonstrate that epithelial cells enrich Ras activity, PIP3, and F-actin to their leading edges during migration within tissues. PIP3 enrichment coincided with, and could enric...

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Vydáno v:Dev Cell
Hlavní autoři: Neumann, Neil M., Perrone, Matthew C., Veldhuis, Jim H., Huebner, Robert J., Zhan, Huiwang, Devreotes, Peter N., Brodland, G. Wayne, Ewald, Andrew J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983037/
https://ncbi.nlm.nih.gov/pubmed/29634937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.03.011
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