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Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria

There is astounding discrepancy between the genome-inscribed production capacity and the set of known secondary metabolite classes from many microorganisms as detected under laboratory cultivation conditions. Genome-mining techniques are meant to fill this gap, but in order to favor discovery of str...

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Vydáno v:Chem Sci
Hlavní autoři: Panter, Fabian, Krug, Daniel, Baumann, Sascha, Müller, Rolf
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5982219/
https://ncbi.nlm.nih.gov/pubmed/29910943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01325j
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