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Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis

The myeloperoxidase system of neutrophils uses hydrogen peroxide and chloride to generate hypochlorous acid, a potent bactericidal oxidant in vitro. In a mouse model of polymicrobial sepsis, we observed that mice deficient in myeloperoxidase were more likely than wild-type mice to die from infection...

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מידע ביבליוגרפי
Main Authors: Gaut, Joseph P., Yeh, George C., Tran, Hung Duy, Byun, Jaeman, Henderson, Jeffrey P., Richter, Grace M., Brennan, Marie-Luise, Lusis, Aldons J., Belaaouaj, Abderrazzaq, Hotchkiss, Richard S., Heinecke, Jay W.
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences 2001
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC59821/
https://ncbi.nlm.nih.gov/pubmed/11593004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.211190298
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