Synthetic Lethality-based Identification of Targets for Anticancer Drugs in the Human Signaling Network

Chemotherapy agents can cause serious adverse effects by attacking both cancer tissues and normal tissues. Therefore, we proposed a synthetic lethality (SL) concept-based computational method to identify specific anticancer drug targets. First, a 3-step screening strategy (network-based, frequency-b...

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Vydáno v:Sci Rep
Hlavní autoři: Liu, Lei, Chen, Xiujie, Hu, Chunyu, Zhang, Denan, Shao, Zhuo, Jin, Qing, Yang, Jingbo, Xie, Hongbo, Liu, Bo, Hu, Ming, Ke, Kehui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5981615/
https://ncbi.nlm.nih.gov/pubmed/29855504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26783-w
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