APVO210: A Bispecific Anti-CD86-IL-10 Fusion Protein (ADAPTIR™) to Induce Antigen-Specific T Regulatory Type 1 Cells

IL-10 is a potent immunosuppressive cytokine that promotes the differentiation of tolerogenic dendritic cells (DC-10), and the subsequent induction of antigen-specific T regulatory type 1 (Tr1) cells, which suppress immune responses. However, IL-10 acts on multiple cell types and its effects are not...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Pellerin, Laurence, Chen, Ping, Gregori, Silvia, Hernandez-Hoyos, Gabriela, Bacchetta, Rosa, Roncarolo, Maria Grazia
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980965/
https://ncbi.nlm.nih.gov/pubmed/29887861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00881
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