Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation

AIMS: This study aimed to analyse the effects of genetic polymorphisms in drug transporters and metabolizing enzymes, and clinical laboratory data on the pharmacokinetic parameters of apixaban. METHODS: Data were collected from 81 Japanese patients with atrial fibrillation. Pharmacogenomic data were...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Ueshima, Satoshi, Hira, Daiki, Kimura, Yuuma, Fujii, Ryo, Tomitsuka, Chiho, Yamane, Takuya, Tabuchi, Yohei, Ozawa, Tomoya, Itoh, Hideki, Ohno, Seiko, Horie, Minoru, Terada, Tomohiro, Katsura, Toshiya
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980466/
https://ncbi.nlm.nih.gov/pubmed/29457840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13561
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