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Reversibly disulfide cross-linked micelles improve the pharmacokinetics and facilitate the targeted, on-demand delivery of doxorubicin in the treatment of B-cell lymphoma

Doxorubicin (DOX) is commonly used to treat human malignancies, and its efficacy can be maximized by limiting the cardiac toxicity when combined with nanoparticles. Here, we reported a unique type of reversibly disulfide cross-linked micellar formulation of DOX (DOX-DCMs) for the targeted therapy of...

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Publicado en:Nanoscale
Autores principales: Xiao, Kai, Liu, Qiangqiang, Awwad, Nasir Al, Zhang, Hongyong, Lai, Li, Luo, Yan, Lee, Joyce S., Li, Yuanpei, Lam, Kit S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980239/
https://ncbi.nlm.nih.gov/pubmed/29682647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8nr00680f
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