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Pharmacokinetics and pharmacodynamics of the cytolytic anti‐CD38 human monoclonal antibody TAK‐079 in monkey – model assisted preparation for the first in human trial
We are studying the fully human, IgG1λ cytolytic monoclonal antibody TAK‐079, which binds CD38. CD38 is expressed on plasma and natural killer (NK) cells constitutively and upregulated on subsets of B and T lymphocytes upon activation. TAK‐079 cross‐reacts with CD38 expressed by cynomolgus monkeys a...
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| Publicado en: | Pharmacol Res Perspect |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5980133/ https://ncbi.nlm.nih.gov/pubmed/29864242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.402 |
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