Sequentially Triggered Nanoparticles with Tumor Penetration and Intelligent Drug Release for Pancreatic Cancer Therapy

Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive malignancy with a five year survival rate of <5%. The aberrant expression of extracellular matrix (ECM) in the tumor stroma forms a compact physical barrier, which that leads to insufficient extravasation and penetration of nanosized...

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Veröffentlicht in:Adv Sci (Weinh)
Hauptverfasser: He, Xi, Chen, Xinli, Liu, Lisha, Zhang, Yu, Lu, Yifei, Zhang, Yujie, Chen, Qinjun, Ruan, Chunhui, Guo, Qin, Li, Chao, Sun, Tao, Jiang, Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979633/
https://ncbi.nlm.nih.gov/pubmed/29876225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201701070
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