Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture

Colorectal cancer is one of the most common causes of cancer death worldwide. In patients with metastatic colorectal cancer, combination treatment with several anti-cancer drugs is employed and improves overall survival in some patients. Nevertheless, most patients with metastatic disease are not cu...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Usui, Tatsuya, Sakurai, Masashi, Umata, Koji, Elbadawy, Mohamed, Ohama, Takashi, Yamawaki, Hideyuki, Hazama, Shoichi, Takenouchi, Hiroko, Nakajima, Masao, Tsunedomi, Ryouichi, Suzuki, Nobuaki, Nagano, Hiroaki, Sato, Koichi, Kaneda, Masahiro, Sasaki, Kazuaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979580/
https://ncbi.nlm.nih.gov/pubmed/29642386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19041098
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