Specific treatment of autoimmunity with recombinant invariant chains in which CLIP is replaced by self-epitopes

The invariant chain (Ii) binds to newly synthesized MHC class II molecules with the CLIP region of Ii occupying the peptide-binding groove. Here we demonstrate that recombinant Ii proteins with the CLIP region replaced by antigenic self-epitopes are highly efficient in activating and silencing speci...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bischof, Felix, Wienhold, Wolfgang, Wirblich, Christoph, Malcherek, Georg, Zevering, Olayinka, Kruisbeek, Ada M., Melms, Arthur
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC59786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11593032/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.221220998
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