Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis

Ulcerative colitis (UC) patients exhibit elevated histamine, but how histamine exacerbates disease is unclear since targeting histamine 1 receptor (H1R) or H2R is clinically ineffective. We hypothesized that histamine functioned instead through the other colon-expressed histamine receptor, H4R. In h...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Main Authors: Wechsler, Joshua B., Szabo, Alison, Hsu, Chia-Lin, Krier-Burris, Rebecca, Schroeder, Holly, Wang, Ming Y., Carter, Roderick, Velez, Tania, Aguiniga, Lizath M., Brown, Jeff B., Miller, Mendy L., Wershil, Barry K., Barrett, Terrence A., Bryce, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976516/
https://ncbi.nlm.nih.gov/pubmed/29363669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2017.121
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