Noxa/HSP27 Complex Delays Degradation of Ubiquitylated IkBα in Airway Epithelial Cells to Reduce Pulmonary Inflammation

IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced i...

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Veröffentlicht in:Mucosal Immunol
Hauptverfasser: Zhang, Chunyu, Jones, Jane T., Chand, Hitendra S., Wathelet, Marc G., Evans, Christopher M., Dickey, Burton, Xiang, Jialing, Mebratu, Yohannes A., Tesfaigzi, Yohannes
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976511/
https://ncbi.nlm.nih.gov/pubmed/29363670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2017.117
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