Early Treatment of SIV+ macaques with an α(4)β(7) mAb alters virus distribution and preserves CD4(+) T cells in later stages of infection

Integrin α(4)β(7) mediates the trafficking of leukocytes, including CD4(+) T cells, to lymphoid tissues in the gut. Virus mediated damage to the gut is implicated in HIV and SIV mediated chronic immune activation and leads to irreversible damage to the immune system. We employed an immuno-PET/CT ima...

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Veröffentlicht in:Mucosal Immunol
Hauptverfasser: Santangelo, Philip J., Cicala, Claudia, Byrareddy, Siddappa N., Ortiz, Kristina, Little, Dawn, Lindsay, Kevin E., Gumber, Sanjeev, Hong, J. J., Jelicic, Katija, Rogers, Kenneth A., Zurla, Chiara, Villinger, Francois, Ansari, Aftab A., Fauci, Anthony S., Arthos, James
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976508/
https://ncbi.nlm.nih.gov/pubmed/29346349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2017.112
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