Tumor targeting with pH-responsive poly(2-oxazoline)-based nanogels for metronomic doxorubicin treatment

The synthesis of a new nanogel drug carrier system loaded with the anti-cancer drug doxorubicin (DOX) is presented. Poly(2-oxazoline) (POx) based nanogels from block copolymer micelles were cross-linked and covalently loaded with DOX using pH-sensitive Schiff’ base chemistry. DOX loaded POx based na...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Hoelzer, Doerte, Leiske, Meike N., Hartlieb, Matthias, Bus, Tanja, Pretzel, David, Hoeppener, Stephanie, Kempe, Kristian, Thierbach, René, Schubert, Ulrich S.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976466/
https://ncbi.nlm.nih.gov/pubmed/29854280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24806
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