Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH

BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) can advance, if untreated, to liver fibrosis, cirrhosis, hepatocellular carcinoma, liver failure and liver-related death. In the United States, NASH affects approximately 2–5% of the population an...

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Bibliographic Details
Published in:PLoS One
Main Authors: Oniciu, Daniela Carmen, Hashiguchi, Taishi, Shibazaki, Yuichiro, Bisgaier, Charles L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976190/
https://ncbi.nlm.nih.gov/pubmed/29847555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194568
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