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WD-repeat domain proteins: a novel target class?
Antagonism of protein-protein interactions (PPIs) with small molecules is becoming more feasible as a therapeutic approach. However, successful PPI inhibitors tend to target proteins containing deep peptide-binding grooves or pockets as opposed to the much more common large, flat protein interaction...
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| Published in: | Nat Rev Drug Discov |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5975957/ https://ncbi.nlm.nih.gov/pubmed/29026209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd.2017.179 |
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