First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

BACKGROUND: Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax(®)-L) to standard therapy for newly diagnosed glioblastoma. METHODS: After surgery and chemorad...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Liau, Linda M., Ashkan, Keyoumars, Tran, David D., Campian, Jian L., Trusheim, John E., Cobbs, Charles S., Heth, Jason A., Salacz, Michael, Taylor, Sarah, D’Andre, Stacy D., Iwamoto, Fabio M., Dropcho, Edward J., Moshel, Yaron A., Walter, Kevin A., Pillainayagam, Clement P., Aiken, Robert, Chaudhary, Rekha, Goldlust, Samuel A., Bota, Daniela A., Duic, Paul, Grewal, Jai, Elinzano, Heinrich, Toms, Steven A., Lillehei, Kevin O., Mikkelsen, Tom, Walbert, Tobias, Abram, Steven R., Brenner, Andrew J., Brem, Steven, Ewend, Matthew G., Khagi, Simon, Portnow, Jana, Kim, Lyndon J., Loudon, William G., Thompson, Reid C., Avigan, David E., Fink, Karen L., Geoffroy, Francois J., Lindhorst, Scott, Lutzky, Jose, Sloan, Andrew E., Schackert, Gabriele, Krex, Dietmar, Meisel, Hans-Jorg, Wu, Julian, Davis, Raphael P., Duma, Christopher, Etame, Arnold B., Mathieu, David, Kesari, Santosh, Piccioni, David, Westphal, Manfred, Baskin, David S., New, Pamela Z., Lacroix, Michel, May, Sven-Axel, Pluard, Timothy J., Tse, Victor, Green, Richard M., Villano, John L., Pearlman, Michael, Petrecca, Kevin, Schulder, Michael, Taylor, Lynne P., Maida, Anthony E., Prins, Robert M., Cloughesy, Timothy F., Mulholland, Paul, Bosch, Marnix L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975654/
https://ncbi.nlm.nih.gov/pubmed/29843811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1507-6
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