Developmental Lead Exposure and Prenatal Stress Result in Sex-Specific Reprograming of Adult Stress Physiology and Epigenetic Profiles in Brain

Developmental exposure to lead (Pb) and prenatal stress (PS) both impair cognition, which could derive from their joint targeting of the hypothalamic-pituitary-adrenal axis and the brain mesocorticolimbic (MESO) system, including frontal cortex (FC) and hippocampus (HIPP). Glucocorticoids modulate b...

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Bibliografiske detaljer
Udgivet i:Toxicol Sci
Main Authors: Sobolewski, Marissa, Varma, Garima, Adams, Beth, Anderson, David W, Schneider, Jay S, Cory-Slechta, Deborah A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Lead Exposure and Sex-Specific Effects on Stress Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974781/
https://ncbi.nlm.nih.gov/pubmed/29481626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy046
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