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Developmental Lead Exposure and Prenatal Stress Result in Sex-Specific Reprograming of Adult Stress Physiology and Epigenetic Profiles in Brain

Developmental exposure to lead (Pb) and prenatal stress (PS) both impair cognition, which could derive from their joint targeting of the hypothalamic-pituitary-adrenal axis and the brain mesocorticolimbic (MESO) system, including frontal cortex (FC) and hippocampus (HIPP). Glucocorticoids modulate b...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Sobolewski, Marissa, Varma, Garima, Adams, Beth, Anderson, David W, Schneider, Jay S, Cory-Slechta, Deborah A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974781/
https://ncbi.nlm.nih.gov/pubmed/29481626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy046
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