Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner

ATP-dependent chromatin remodellers are mutated in more than 20% of human cancers. The consequences of these mutations on enzyme function are poorly understood. Here, we characterise the effects of CHD4 mutations identified in endometrial carcinoma on the remodelling properties of dMi-2, the highly...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kovač, Kristina, Sauer, Anja, Mačinković, Igor, Awe, Stephan, Finkernagel, Florian, Hoffmeister, Helen, Fuchs, Andreas, Müller, Rolf, Rathke, Christina, Längst, Gernot, Brehm, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974244/
https://ncbi.nlm.nih.gov/pubmed/29844320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04503-2
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