Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease

T-cell-mediated immune responses play a fundamental role in controlling Mycobacterium tuberculosis (M. tuberculosis) infection, and traditionally, this response is thought to be mediated by Th1-type CD4(+) T-cells secreting IFN-γ. While studying the function and specificity of M. tuberculosis-reacti...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Orlando, Valentina, La Manna, Marco P., Goletti, Delia, Palmieri, Fabrizio, Lo Presti, Elena, Joosten, Simone A., La Mendola, Carmela, Buccheri, Simona, Ottenhoff, Tom H. M., Dieli, Francesco, Caccamo, Nadia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974168/
https://ncbi.nlm.nih.gov/pubmed/29875774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01119
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