Rheumatic Disease: Protease-Activated Receptor-2 in Synovial Joint Pathobiology

Protease-activated receptor-2 (PAR2) is one member of a small family of transmembrane, G-protein-coupled receptors. These receptors are activated via cleavage of their N terminus by serine proteases (e.g., tryptase), unveiling an N terminus tethered ligand which binds to the second extracellular loo...

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Bibliographische Detailangaben
Veröffentlicht in:Front Endocrinol (Lausanne)
Hauptverfasser: McCulloch, Kendal, McGrath, Sarah, Huesa, Carmen, Dunning, Lynette, Litherland, Gary, Crilly, Anne, Hultin, Leif, Ferrell, William R., Lockhart, John C., Goodyear, Carl S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Endocrinology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974038/
https://ncbi.nlm.nih.gov/pubmed/29875735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2018.00257
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