Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate

Glutarate is a five carbon platform chemical produced during the catabolism of l-lysine. It is known that it can be catabolized through the glutaryl-CoA dehydrogenation pathway. Here, we discover that Pseudomonas putida KT2440 has an additional glutarate catabolic pathway involving l-2-hydroxyglutar...

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Vydáno v:Nat Commun
Hlavní autoři: Zhang, Manman, Gao, Chao, Guo, Xiaoting, Guo, Shiting, Kang, Zhaoqi, Xiao, Dan, Yan, Jinxin, Tao, Fei, Zhang, Wen, Dong, Wenyue, Liu, Pan, Yang, Chen, Ma, Cuiqing, Xu, Ping
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974017/
https://ncbi.nlm.nih.gov/pubmed/29844506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04513-0
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